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Hypertension NSAIDs, including NAPRELAN can lead to onset of new hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events. Remember that your doctor has prescribed naprosyn internete recepto this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSAIDs. Naproxen has been associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking naproxen Wilkinson et al. Because of the possible adverse effects of prostaglandin-inhibiting drugs on neonates, use in nursing mothers should be avoided. Dosage is based on your medical condition and response to therapy. Abrupt discontinuation of corticosteroids may lead to disease exacerbation.