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Hydrocodone exhibits complex pattern of metabolism including O- demethylation, N-demethylation and 6-keto reduction to the corresponding 6- and 6- hydroxymetabolites. Com provides free, accurate and independent advice on more than 24,000 prescription drugs, over-the-counter medicines natural products. The absence of warning for given drug or drug combination in no way should be construed to indicate that recreation use of hydrocodone the drug or drug combination is safe, effective or appropriate for any given patient. Elimination of acetaminophen is principally by liver metabolism conjugation and subsequent renal excretion of metabolites.
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